منابع مشابه
Lack of chondrotoxicity of ofloxacin otic solution on the auditory ossicle cartilages of juvenile guinea pigs.
The effect of 0.3% otic solution of ofloxacin on the cartilages constituting the epiphyses of the auditory ossicles and the wall of the auditory tube was histologically examined after 30-day repeated intratympanic administration to juvenile male guinea pigs aged 4 weeks. Ofloxacin showed no chondrotoxicity for the cartilages and, in some but not all animals, reduced haemorrhage and neutrophil i...
متن کاملTopical ciprofloxacin/dexamethasone otic suspension is superior to ofloxacin otic solution in the treatment of children with acute otitis media with otorrhea through tympanostomy tubes.
OBJECTIVE To determine the efficacy and safety of topical ciprofloxacin/dexamethasone otic suspension compared with ofloxacin otic solution in the treatment of acute otitis media with otorrhea through tympanostomy tubes (AOMT) in pediatric patients. METHODS This multicenter, prospective, randomized, observer-masked, parallel-group study was conducted at 39 sites in 599 children aged >or=6 mon...
متن کاملSafety of ofloxacin otic and other ototopical treatments in animal models and in humans.
To assess the safety of topical agents in the middle ear, animal studies were reviewed. Compared with aminoglycoside-containing preparations, which caused significant loss of hair cells in the basal turn of the cochlea, ofloxacin caused no loss of hair cells, even at concentrations higher than used clinically. Moreover auditory brainstem testing revealed no change in auditory thresholds in the ...
متن کاملOtic polyp.
Patients usually present with a solitary, polypoid, reddish, friable mass. The entire specimen is usually processed in order to rule out a concurrent cholesteatoma. Pathologic examination will reveal a granulation-type tissue with edematous stroma and a high density of capillaries (figure 1) associated with chronic inflammatory cells, including plasma cells, lymphocytes, histiocytes, and eosino...
متن کاملOtotoxicity of aluminum acetate/benzethonium chloride otic solution in the chinchilla animal model.
OBJECTIVES/HYPOTHESIS To determine the ototoxic potential of aluminum acetate (0.5%)/benzethonium chloride (0.03%) otic solution in the chinchilla animal model. STUDY DESIGN A randomized, prospective, controlled study was conducted in the chinchilla animal model. METHODS Fourteen female chinchillas were used. After an incision was made in each tympanic membrane, baseline auditory brainstem ...
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ژورنال
عنوان ژورنال: Practica Oto-Rhino-Laryngologica
سال: 1992
ISSN: 1884-4545,0032-6313
DOI: 10.5631/jibirin.85.293